Nestled in the Central district of Naples, B&B Casa Napoli is only 12 minutes' walk from the Stazione Napoli Centrale.

Located a mere 1.6 km from the Capodimonte Astronomical Observatory, the bed & breakfast is also just near Napoli Piazza Garibaldi railway station. The area includes such religious sights as the funerary chapel "Museo Cappella Sansevero" (2.4 km) and the lavishly decorated 8th-century Via San Gregorio Armeno Church (1.5 km). The Basilica Museum Complex of St. Clare Church is approximately 10 minutes' drive away, while Piazza Garibaldi underground station is 350 metres from the B&B Casa Napoli. There is Meridionale bus stop merely 250 metres away.

The rooms comprise a balcony complete with an air conditioner, as well as a flat-screen TV with satellite channels. The bedrooms come with extra-long beds. Bathrooms feature a bidet, a separate toilet, and a shower along with hairdryers and bath sheets.

Situated within easy reach of B&B Casa Napoli, the restaurant Da Pellone offers a Mediterranean menu.