Located in Spaccanapoli, which is a straight and narrow street 19 minutes' stroll from Castel Nuovo Medieval Castle, Palazzo Carafa Santangelo Bed & Breakfast Naples boasts an archaeological museum. The bed & breakfast resides in a historic building featuring such decor details as parquet floors.

This 4-star hotel is notable for its prime location only 250 metres from the funerary chapel "Museo Cappella Sansevero" and not far from Piazza Cavour train station. The opulent Church of San Domenico Maggiore is around 5 minutes' walk away, while the Church of Saints Filippo and Giacomo is merely 10 minutes' walk from the Palazzo Carafa Santangelo Bed & Breakfast. The ancient underground Catacombe di San Gennaro Burial Grounds is 2.6 km away, while Università underground station is a short way from the property. The hotel is located 5 km from Capodichino airport and within 10 minutes' walk of Foria - Duomo bus stop.

Ironing equipment and an air conditioner, along with a mini-fridge-bar, tea and coffee-making facilities, provide in-room convenience at the Palazzo Carafa Santangelo Bed & Breakfast Naples. Furnished with a writing table, they also have soundproof windows. Bathrooms inlude a bidet, a separate toilet, and a shower, and such fine comforts as hair dryers and bath sheets.

Palazzo Carafa Santangelo Bed & Breakfast offers a continental breakfast which includes fresh pastries, fresh fruits, and cheese. Sorbillo, located just moments from this property, will spoil you with Neapolitan cuisine.