Located approximately a 10-minute ride from the Naples National Archaeological Museum, the comfortable 4-star Palazzo Santa Maria Bed & Breakfast Naples offers Wi-Fi throughout the property and a car park. The recently renovated bed & breakfast is a good starting point for Naples's sports attractions, including the Arturo Collana Stadium, which is only 1.9 km away.

This Naples hotel in the Vittorio Emanuele district is around 5 minutes by car from the baroque church "Certosa e Museo di San Martino" and in the vicinity of such shopping venues as the traffic-free square "Piazza del Plebiscito". Standing just 650 metres from the Naples Underground, the Palazzo Santa Maria Bed & Breakfast is 2.2 km from Cimitero delle Fontanelle Cemetery. The area is notable for educational places like Parthenope University of Naples, situated nearly 20 minutes on foot from the accommodation. The hotel lies 900 m from Vanvitelli underground station and a short way from Piazza Amedeo train station.

The rooms at the Palazzo Santa Maria Bed & Breakfast Naples are allergy-friendly and fitted with free Wi-Fi and a flat-screen TV with satellite channels as well as a mini fridge bar and coffee/tea making equipment. There is also a private bathroom. Bathrooms have a bidet, a separate toilet, and a shower, along with hairdryers and bath sheets.

While staying at Palazzo Santa Maria Bed & Breakfast, guests can choose from dining options nearby, such as Gran Caffe Gambrinus, located merely a 14-minute walk away, or Pizzeria Da Eduardo at a 5-minute walking distance.