Located 800 metres from the Sant'Anna dei Lombardi, Casa Giupa Hotel Naples is 5 minutes on foot from the grand Fountain of Neptune.

The 13th-century Castel Nuovo Castle is around 400 metres away, while Montesanto train station is a short way from this guest house. The 3-star hotel lies 10 minutes on foot from the public shopping gallery "Galleria Umberto I". The Casa Giupa is also not far from the Bourbon Gallery and Capolinea Sita bus station is 0.9 km away. This property is located 10 minutes' walk from Municipio underground station and a 15-minute drive will be enough to get to Capodichino airport.

The hotel offers rooms with a balcony and a dining area featuring an air conditioner, along with a flat-screen TV with satellite channels. They are appointed with a writing table, and also feature tea and coffee making facilities. Bathrooms include a bidet, a separate toilet, and a shower, and such comforts as a hair dryer and bath sheets.

The seafood restaurant Trattoria da Nennella lies a few moments from Casa Giupa Hotel.