Nestled just 1.6 km from the funerary chapel "Museo Cappella Sansevero" and nearly 10 minutes' walk from Materdei underground station, the comfortable 4-star Casa San Felice Hotel Naples proudly boasts an archaeological museum. There is also a car park.

The guest house has a convenient setting just 1.3 km from the Naples Historic Centre, while natural sights like the Orto Botanico di Napoli are merely 1.7 km away. The 17th-century monastery complex "Certosa e Museo di San Martino" is about a 10-minute drive from the Casa San Felice Naples, and Capodichino airport is 5 km away. One of the most important attractions in Naples is the basilica Catacombs of San Gaudioso Church, located in close proximity to the hotel. The property provides a place to stay 450 m from the Piazza Cavour train station.

The rooms comprise a patio complete with air conditioning, as well as free wireless internet and a flat-screen TV with satellite channels. Bathrooms offer a bidet, a separate toilet, and a shower, along with comforts such as hair dryers and shower caps.

Guests may find the restaurant Sorbillo within a few blocks of Casa San Felice Hotel.