Found in the Orto Botanico district, Independenthouse28 Hotel Naples welcomes guests within 600 metres of the historic Botanical Garden of Naples and features an archaeological museum. This hotel also includes a car park.

Situated 2.3 km from the funerary chapel "Museo Cappella Sansevero", the 4-star guest house is a few moments from Piazza Carlo III. The Independenthouse28 in Naples is a 25-minute walk from Chiesa dei Santi Filippo e Giacomo Church. A short way from the ancient Porta Capuana City Gate is a perk for guests staying at this property. Carlo III bus stop is 250 metres from the hotel and 1.6 km from is enough to get to Naples Central train station.

A living room are included in the rooms for guests' convenience.

The restaurant Pizzeria La Ruota is situated in close proximity to the Independenthouse28 Naples.