Located 1.7 km from the mighty Museum Complex of St. Clare Basilica, La Residenza Napoli Centro Citta Hotel Vico Equense is a 5-minute walk from the 17th century Royal Palace of Naples.

The public shopping gallery "Galleria Umberto I" is 450 metres away, while Montesanto train station is in the vicinity of this hotel. The Via Chiaia lies a 10-minute walk away. There is the funerary chapel "Museo Cappella Sansevero" 2 km away, and Capolinea Sita bus station is within 700 metres of the La Residenza Napoli Centro Citta. Municipio tube station is also in close proximity to this hotel.

The seafood restaurant Osteria Il Gobbetto is situated a 5-minute stroll from the property.