The 4-star Main - Duomo Hotel Naples sits just 9 minutes' walk from the MADRE Museum and offers a barber shop. This Naples hotel has views of the city and features Wi-Fi throughout the property.

Nearby places of interest include the 13th-century Castel Nuovo Castle, located merely 1.4 km from the guest house, and the Naples National Archaeological Museum, which is merely 1.6 km away. The Main - Duomo Naples is situated around 500 metres from the baroque Catholic church "Museo dell'Opera Pia Purgatorio ad Arco" and in the vicinity of Università underground station. The property is also within 10 minutes' drive of the star-shaped Castel Sant'Elmo and EAV - Capolinea Porta Nolana bus station is approximately a 10-minute walk away. Piazza Cavour train station lies a short way from the hotel.

All allergy-free rooms at Main - Duomo Hotel are equipped with a flat-screen TV with satellite channels along with a mini-fridge-bar, coffee and tea making equipment for self-catering. Furnished with a writing desk, they also have soundproof windows. Guests have access to a bidet, a separate toilet, and a shower, as well as bathroom comforts such as hair dryers and towels.

L'Antica Pizzeria da Michele is located next to the Main - Duomo and serves Campania dishes, 500 metres away.