Offering air-conditioned rooms and Wi-Fi in the rooms, Manichiello Hotel Naples is just 1.1 km from the Piazza San Gaetano and 25 minutes' walk from the 18th-century National Museum of Capodimonte. The guest house offers quiet views of the street as well as proximity to the ancient Porta Capuana City Gate, which is 350 metres away.

The comfortable hotel in the Central district, a 30-minute stroll from the Naples National Archaeological Museum. The Manichiello stands a stone's throw from Piazza Garibaldi tube station. Along with other cultural attractions the Museum of the Treasure of San Gennaro is nestled 1.2 km from this property. Lucci Accademia della Moda bus stop is 150 metres from the 4-star hotel and just around the corner from is enough to get to Napoli Piazza Garibaldi train station.

The rooms at the Manichiello Naples provide guests with a flat-screen TV with satellite channels, as well as comforts such as climate control. Also, there is a personal safe, a mini fridge bar, coffee and tea making facilities provided. The bathroom is equipped with a bidet, a walk-in shower, and a separate toilet, along with hairdryers and a shower cap.

An Italian breakfast is provided daily. Located 7 minutes on foot from Manichiello Hotel, the bakery Antico Forno delle Sfogliatelle Calde Fratelli Attanasio offers a Neapolitan menu.