Manichiello Hotel Naples is nestled in the Central district, 25 minutes' walk from the funerary chapel "Museo Cappella Sansevero", features an archaeological museum. Guests can enjoy Wi-Fi in the rooms.

Located 350 metres from Napoli Piazza Garibaldi railway station, this guest house stands in close proximity to the ancient Porta Capuana City Gate. The Manichiello also gives access to the basilica Catacombs of San Gaudioso Church, which is a 30-minute walk away. There is the Museum of the Treasure of San Gennaro 1.1 km away, while Flix Napoli bus station is just 450 m from this 4-star hotel. Piazza Garibaldi underground station is at a distance of only a few steps from the property.

The rooms at the Manichiello Naples provide guests with a flat-screen TV with satellite channels, as well as comforts such as an iron and climate control. They are appointed with a writing desk, and also feature a minibar fridge, coffee and tea makers. The bathroom is equipped with a bidet, a walk-in shower, and a separate toilet, along with hairdryers and bath sheets.

An Italian breakfast is provided daily. The bakery Antico Forno delle Sfogliatelle Calde Fratelli Attanasio is situated a 7-minute stroll from Manichiello Hotel.