Located 25 minutes' stroll from the 13th - century Castel Nuovo Castle, Margherita 109 Naples hotel is fairly close to the Church of the Most Holy Redeemer. This guest house also includes a car park.

The art museum "Museo PAN" is 0.6 km away, while Piazza Amedeo train station is just 350 metres from the 4-star hotel. The Margherita 109 gives access to the ornate 18th-century opera house "San Carlo Theatre", which is 20 minutes' walk away. The 18th-century National Museum of Capodimonte is 3.5 km away, while Quattro Giornate underground station is a short way from this property. The hotel is 5 minutes' walk from Vittorio Emanuele - Parco Margherita bus station.

Margherita 109 hotel offers rooms with a balcony and a dining area featuring an air conditioner, along with a flat-screen TV with satellite channels. They are appointed with a writing table, and also feature a minibar fridge, coffee and tea making facilities. Bathrooms include a bidet, a separate toilet, and a shower, and such comforts as hairdryers and bath sheets.

Guests can dine at the seafood restaurant Hachi Ristorante Giapponese, which is 2 km away.