Offering air-conditioned rooms and Wi-Fi in public areas, the 3-star Hotel Neapolis is 900 metres from Museo d'Arte Contemporanea Donnaregina and only a 5-minute walk from the funerary chapel "Museo Cappella Sansevero". Guests can take advantage of a private parking lot for EUR 35 per day nearby.

The hotel is in the very heart of Naples, right near the lavishly decorated 8th-century Via San Gregorio Armeno Church. The Neapolis Naples is within 400 metres of the ornate basilica "Church of San Domenico Maggiore" and 5 km from Capodichino airport. Nature lovers will appreciate the vicinity of Bacino di raddobbo borbonico, which is around 20 minutes' walk away. The traffic-free square "Piazza del Plebiscito" is 2.2 km away, while Museo underground station is just around the corner from this Naples hotel. Costantinopoli bus stop is within 5 minutes' walk of Hotel Neapolis and within 10 minutes' walk of is enough to get to Montesanto train station.

Furnished with a sofa bed and a study desk, some of the 12 rooms feature individual climate control and central heating along with Wi-Fi. Featuring a private bathroom with a roll-in shower, certain rooms also have views of the inner courtyard. Bathrooms include a walk-in shower and a separate toilet, and such comforts as hair dryers and bath sheets. A kitchenette with a microwave, coffee and tea making facilities, and a washing machine are available in an apartment.

The Neapolis welcomes guests with a daily kid-friendly buffet breakfast. There is a lounge bar onsite. Dining options include Sorbillo, which offers Neapolitan cuisine and is situated about 100 metres away.