Located 1.9 km from the MUSA - University Museum of Sciences and Arts, Opera 5 Hotel Naples is a 6-minute walk from the Piazza Trieste e Trento.

The traffic-free square "Piazza del Plebiscito" is 550 metres away, while Montesanto train station is not far from this hotel. Guests will also appreciate proximity to the Spaccanapoli, which is a 14-minute walk away. There is the lavishly decorated 8th-century Via San Gregorio Armeno Church 1.6 km away, while Capolinea Sita bus station is within 700 metres of the Opera 5. The nearest tube station to this 4-star guest house is Municipio, a 5-minute stroll away. The property is within easy reach of Naples International airport, the distance is just 5 km.

The rooms at Opera 5 Hotel provide guests with a flat-screen TV with satellite channels and wireless internet, as well as comforts such as climate control. Guestrooms also include an electric kettle and a fridge. Bathrooms are appointed with a bidet, a separate toilet, and a shower along with hair dryers and bath sheets.

The seafood restaurant Trattoria del Golfo is situated only a few steps from the hotel.