Featuring an archaeological museum, the 3-star smoke-free Palazzo Sant'Antonio Hotel Naples offers a location around 10 minutes' drive from the large public square "Piazza del Plebiscito". The Piazza dei Martiri is located 2.8 km from this Naples hotel, boasting a rooftop bar and city views.

The hotel is about 5 km from Capodichino airport and within 20 minutes' walk of such cultural venues as the Naples National Archaeological Museum. You can find the Piazza San Gaetano, which is a great place to explore the area, 2.1 km from the Palazzo Sant'Antonio Naples. Standing approximately a 25-minute walk away, the basilica Catacombs of San Gaudioso Church is a hard-to-miss divine tourist destination. The nearest bus stop is Santacroce - Parco Nuovo, located just 150 metres away, and Montesanto train station is merely 500 metres away.

The air-conditioned rooms at Palazzo Sant'Antonio Hotel are fitted with free wireless internet, some of them feature sound-proof windows. Bathrooms have a separate toilet and a shower, along with a hair dryer and a shower cap.

An Italian breakfast is also offered onsite. Trattoria da Nennella serves various kinds of Neapolitan dishes within reach of the property.