Located within 300 metres of the 700s Via San Gregorio Armeno Church, San Gennaro S Room Naples hotel is a 5-minute walk from the 1st-floor Pio Monte della Misericordia Gallery.

The funerary chapel "Museo Cappella Sansevero" is 8 minutes' stroll away, while Piazza Cavour train station is a short way from this guest house. The 3-star hotel also gives access to the mighty Museum Complex of St. Clare Basilica, which is about 800 metres away. There is the 18th-century National Museum of Capodimonte 2 km away, and EAV - Capolinea Porta Nolana bus station is 10 minutes' stroll from the San Gennaro S Room. This property is located not far from Università underground station and a 10-minute drive will be enough to get to Capodichino airport.

The hotel offers rooms with a balcony featuring an air conditioner, along with a flat-screen TV with satellite channels. They are appointed with a writing desk, and also feature tea and coffee making equipment. Bathrooms are fitted with a bidet, a separate toilet, and a shower as well as a hairdryer and towels.

San Gennaro S Room hotel is 550 metres from the restaurant Sorbillo.